【單股DNA--單株抗體】C3B6 訂購貨號#4350-MC-100。UVssDNA monoclonal antiobdy。應用於UV損傷皮膚之研究

UVssDNA單股DNA--單株抗體 (C3B6)

UVssDNA單株抗體(C3B6)

Trevigen is pleased to provide highly qualified enzymes, antibodies, and assay kits for DNA damage and repair research. As always, our products are accompanied by detailed product data sheets or instructions for use, and backed with expert technical support.

DNA Repair Deficient Cell Lines

DNA repair pathways maintain the integrity of the genome reducing the onset of cancer, disease and aging phenotypes. To further study repair pathways, Trevigen offers panels of human cell lines each deficient in proteins associated with DNA repair. This consists of cell lines deficient for proteins in the Base Excision Repair Pathway, Non Homologous End Joining, Homologous Recombination and Mismatch Repair. For the availability of other DNA repair deficient cell lines contact Trevigen.

PARP/PAR/PARG

PARP-1 contributes to the sequence of events that occurs during DNA base excision repair. Trevigen offers kits that measure the in vivo and in vitro activities of PARP and PARG.

CometAssay^®

The single cell gel electrophoresis or CometAssay^®is a state-of-the-art technique for quantitating DNA damage and repair from in vivo and in vitro samples of eukaryotic cells and some prokaryotic cells. In conjunction with Trevigen’s new CometAssay® Electrophoresis System, which eliminates known causes of assay variability, it is the only technique that directly measures DNA damage in individual cells and as a result has rapidly gained importance in the fields of genetic toxicology and human biomonitoring.

DNA Repair Enzymes and Antibodies

Trevigen’s unique FLARE™ Assays characterize DNA damage in single cells using a variety of DNA repair enzymes that recognize oxidative and UV damage in conjunction withTrevigen’s CometAssay^® Electrophoresis System. A variety of DNA repair enzymes and antibodies are available as individual components with optimized assay conditions and buffers for research in areas of double-strand break repair, base excision repair, DNA methylation, oxidative damage, UV damage, and radiation damage.

	Anti-UVssDNA Monoclonal Antibody (clone C3B6)
中文名稱	UVssDNA單株抗體(C3B6)
供應商	Trevigen	產品貨號	4350-MC-100
產品資料	應用於UV損傷皮膚之研究、UV損傷DNA之修復機理。
免疫原	UV輻射的小牛胸腺偶聯甲基化BSA之單鏈DNA (UV輻射的dT-mBSA聚合物)
來源宿主	抗體subtype為IgG1/κ。抗體經由小鼠腹水免疫後，再純化。抗體力價高。抗體濃度含有1mg/mlPBS 和0.01%疊氮鈉。
反應性	識別單鏈DNA中4個核苷酸長度的(6-4)-dipyrimidines。能特異識別(6-4)-dithymidine，不能識別(6-4)-dicytidines or cyclo-butadipyrimidines，與寡核苷酸序列裡的(6-4)-thymine/cytidines有較低的交叉反應。 Immunological assays for DNA photoproducts provide a rapid means to quantitate photodamage in DNA. Photochemical damage is considered to be an important factor in the development of skin cancer. Sensitive immunological methods that detect individual DNA adducts facilitate the study of the biological significance of DNA lesions. Trevigen’s monoclonal UVssDNA antibody (clone C3B6) (cat# 4350-MC-100) detects (6-4)-dipyrimidine photoproducts. Specificity has been demonstrated for (6-4)-dithymidine, whereas the (6-4)-dicytidines or cyclobutadipyrimidines are not recognized. A low level of cross reactivity was observed with repeating (6-4)-thymine/cytidines within an oligonucleotide sequence. The UVssDNA clone C3B6 antibody recognizes (6-4)-dipyrimidines in single stranded DNA at least 4 nucleotides long.
保存建議	保存於-20貯存，避免反復冷凍解凍。

【供應廠商】萊恩生物科技有限公司

【公司電話】04-2523-9639

【業務專員】陳俊豪 0937-229803

【電子信箱】biolion0819@gmail.com